Kudo T, Wada J A
Division of Neuroscience, University of British Columbia, Vancouver, Canada.
Electroencephalogr Clin Neurophysiol. 1995 Jul;95(1):63-8. doi: 10.1016/0013-4694(95)00013-o.
The effect of unilateral lesions of the claustrum was examined in cats treated with D,L-allylglycine. Prior to the lesion, intermittent light stimulation (ILS) induced (a) myoclonic jerking associated with generalized spike, or polyspike and wave discharge, maximal in the subcortical structures monitored and the cortical visual area, and (b) bisymmetrical generalized-onset tonic-clonic convulsions associated with sustained spike discharge in the motor cortex bilaterally. Subsequent to a unilateral lesion of the claustrum, ILS-induced electro-clinical manifestations of myoclonic jerking remained unchanged. However, the bisymmetrical convulsive pattern transformed into a partial onset secondarily generalized convulsive pattern beginning in the intact hemisphere. It is concluded that the claustrum plays an important role for access of visual afferents to the motor mechanism responsible for ILS-induced convulsive seizure.
在接受D，L-烯丙基甘氨酸治疗的猫中，研究了单侧屏状核损伤的影响。在损伤前，间歇性光刺激（ILS）诱发：（a）与全身性棘波或多棘波和慢波放电相关的肌阵挛性抽搐，在监测的皮质下结构和皮质视觉区域中最为明显；（b）与双侧运动皮质中持续的棘波放电相关的双侧对称全身性强直阵挛性惊厥。单侧屏状核损伤后，ILS诱发的肌阵挛性抽搐的电临床表现保持不变。然而，双侧对称的惊厥模式转变为从完整半球开始的部分性发作继以全身性发作的惊厥模式。得出的结论是，屏状核对视觉传入信号进入负责ILS诱发惊厥发作的运动机制起着重要作用。
