C5趋化片段诱导白细胞产生组织因子活性：补体与凝血之间的联系。
C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation.
作者信息
Muhlfelder T W, Niemetz J, Kreutzer D, Beebe D, Ward P A, Rosenfeld S I
出版信息
J Clin Invest. 1979 Jan;63(1):147-50. doi: 10.1172/JCI109269.
Abstract
Complement-activated human plasma causes generation of tissue factor in human leukocytes. This phenomenon appears to be related to the fifth component of complement (C5) as demonstrated by the use of C5 deficient-plasma and suppression of activity with antibody to C5. Isolation of the chemotactic factor from activated serum or trypsinization of purified C5 reproduces the phenomenon. These data provide evidence for a direct link between complement products and activation of the coagulation system. Because chemotactic peptides from C5 can be generated by a variety of enzymes, our findings suggest a relationship between complement, coagulation, and inflammation.
摘要
补体激活的人血浆可导致人白细胞中组织因子的生成。使用C5缺陷血浆以及用抗C5抗体抑制活性表明，这种现象似乎与补体的第五成分（C5）有关。从活化血清中分离趋化因子或对纯化的C5进行胰蛋白酶处理可重现该现象。这些数据为补体产物与凝血系统激活之间的直接联系提供了证据。由于来自C5的趋化肽可由多种酶产生，我们的发现提示补体、凝血和炎症之间存在关联。
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J Clin Invest. 1979 Jan;63(1):147-50. doi: 10.1172/JCI109269.
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