通过补体激活在血清中产生成纤维细胞趋化因子。
Generation of a fibroblast chemotactic factor in serum by activation of complement.
作者信息
Postlethwaite A E, Snyderman R, Kang A H
出版信息
J Clin Invest. 1979 Nov;64(5):1379-85. doi: 10.1172/JCI109595.
Abstract
When serum complement is activated by either the classical or alternative pathways, a factor with an apparent 80,000 mol wt is generated that is chemotactic for human dermal fibroblasts. The origin of this serum-derived chemotactic factor (SDCF) is not known; however, it may be a cleavage product from C5 because it is inactivated by monospecific antiserum to human C5, and it is not generated when the complement system is activated in human serum deficient in C5. SDCF is not chemotactic for human neutrophils or monocytes. Because SDCF is generated when serum complement is activated, it may function in vivo to attract connective tissue fibroblasts to sites of inflammatory reactions in which the complement system participates.
摘要
当血清补体通过经典途径或替代途径被激活时，会产生一种表观分子量为80,000的因子，该因子对人皮肤成纤维细胞具有趋化作用。这种血清来源的趋化因子（SDCF）的起源尚不清楚；然而，它可能是C5的裂解产物，因为它被抗人C5单特异性抗血清灭活，并且当在缺乏C5的人血清中激活补体系统时不会产生。SDCF对人中性粒细胞或单核细胞没有趋化作用。由于血清补体激活时会产生SDCF，它可能在体内发挥作用，将结缔组织成纤维细胞吸引到补体系统参与的炎症反应部位。
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