Taylor R H, Menzies-Gow N, Lovell D, La Brooy S J, Misiewicz J J
Lancet. 1978 Apr 1;1(8066):686-8. doi: 10.1016/s0140-6736(78)90799-7.
Four patients who apparently had benign gastric ulcer (G.U.) were treated with cimetidine. The ulcers healed and their symptoms disappeared. However, when cimetidine was stopped the symptoms recurred. Intramucosal cancer was found only at histopathological examination of the resected stomachs in two of the four patients, and in all the cases malignancy had not been detected by the initial serial biopsies and brush cytology. Relief of symptoms of malignant gastric ulcers by cimetidine may delay diagnosis and appropriae treatment.
4例明显患有良性胃溃疡（G.U.）的患者接受了西咪替丁治疗。溃疡愈合且症状消失。然而，当停用西咪替丁时，症状复发。在这4例患者中的2例，仅在切除胃的组织病理学检查中发现了黏膜内癌，并且在所有病例中，最初的系列活检和刷检细胞学均未检测到恶性肿瘤。西咪替丁缓解恶性胃溃疡症状可能会延迟诊断和适当治疗。
