Villringer K, Jäger H, Dichgans M, Ziegler S, Poppinger J, Herz M, Kruschke C, Minoshima S, Pfister H W, Schwaiger M
Department of Nuclear Medicine, Curatorium for Immunodeficiency, Munich, Germany.
J Comput Assist Tomogr. 1995 Jul-Aug;19(4):532-6. doi: 10.1097/00004728-199507000-00004.
The aim of this study was to evaluate the potential of FDG-PET in the differential diagnosis of CNS lesions in patients with AIDS, particularly to differentiate between toxoplasmosis and lymphoma.
We examined 11 AIDS patients, 6 with toxoplasmosis, 1 with a tuberculoma, and 4 with a primary CNS lymphoma. The FDG uptake within the lesion was compared with the uptake in a contralateral brain area [standardized uptake value (SUV)].
In all subjects with cerebral infections (toxoplasmosis, tuberculoma), the SUV ratio was significantly (p < 0.05) lower than the SUV ratio in patients with lymphoma (range of 0.3-0.7 vs. 1.7-3.1) with no overlap of the uptake values.
In conclusion, FDG-PET may help to characterize these lesions metabolically and play an important role in the clinical management of AIDS patients with CNS involvement.
本研究的目的是评估氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在艾滋病患者中枢神经系统（CNS）病变鉴别诊断中的潜力，特别是区分弓形虫病和淋巴瘤。
我们检查了11例艾滋病患者，其中6例患有弓形虫病，1例患有结核瘤，4例患有原发性中枢神经系统淋巴瘤。将病变内的FDG摄取与对侧脑区的摄取进行比较[标准化摄取值（SUV）]。
在所有脑部感染（弓形虫病、结核瘤）患者中，SUV比值显著低于淋巴瘤患者（p < 0.05）（范围为0.3 - 0.7对比1.7 - 3.1），摄取值无重叠。
总之，FDG-PET可能有助于从代谢角度对这些病变进行特征描述，并在艾滋病合并中枢神经系统受累患者的临床管理中发挥重要作用。
