Hoffman J M, Waskin H A, Schifter T, Hanson M W, Gray L, Rosenfeld S, Coleman R E
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
J Nucl Med. 1993 Apr;34(4):567-75.
Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG-PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.
诸如CT或MRI等结构成像研究无法准确区分艾滋病患者脑部的感染性病变和恶性病变。我们对11例患有艾滋病且有中枢神经系统（CNS）病变的患者进行了18F-氟-2-脱氧葡萄糖（FDG）和正电子发射断层扫描（PET）研究。FDG-PET能够准确区分CNS病变的恶性（淋巴瘤）病因和非恶性病因。对图像进行了定性视觉检查以及使用计数比率的半定量分析，结果相似。FDG-PET可能有助于管理患有CNS病变的艾滋病患者，因为高FDG摄取很可能代表恶性过程，应进行活检以确诊，而不是按感染性病变进行经验性治疗。
