Orjala J, Nagle D, Gerwick W H
College of Pharmacy, Oregon State University, Corvallis 97331, USA.
J Nat Prod. 1995 May;58(5):764-8. doi: 10.1021/np50119a019.
Guided by ichthyotoxic activity against goldfish, a new lipopeptide, malyngamide H [1], and its corresponding free acid, 7-methoxytetradec-4(E)-enoic acid [2], have been isolated from the tropical marine cyanobacterium Lyngbya majuscula. The structure of the new carbon skeleton borne by malyngamide H was elucidated on the basis of spectroscopic analysis, mainly 2D nmr. The absolute stereochemistry of the cyclohexenone moiety of malyngamide H [1] was deduced by a combination of 2D NOESY and exciton chirality circular dichroism spectroscopy.
以对金鱼的鱼毒性活性为指导，从热带海洋蓝藻巨大鞘丝藻（Lyngbya majuscula）中分离出一种新的脂肽——马琳酰胺H [1]及其相应的游离酸——7-甲氧基十四碳-4（E）-烯酸[2]。基于光谱分析，主要是二维核磁共振，阐明了马琳酰胺H所具有的新碳骨架的结构。通过二维核欧沃豪斯效应光谱（2D NOESY）和激子手性圆二色光谱相结合的方法，推断出马琳酰胺H [1]环己烯酮部分的绝对立体化学结构。
