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Neuropsin-dependent and -independent behavioral tagging.神经蛋白酶依赖和不依赖的行为标记。
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Neuropsin in mental health.神经蛋白酶与心理健康。
J Physiol Sci. 2020 May 15;70(1):26. doi: 10.1186/s12576-020-00753-2.
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Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.人类 KLK8/neuropsin 变构环网络的特异性和活性调节的结构决定因素。
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A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.丝氨酸蛋白酶 KLK8 作为记忆中的调控因子出现：微管蛋白依赖性神经元形态和 PKA-CREB 信号转导。
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Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model.脆性X综合征小鼠模型海马CA1锥体神经元中细胞类型特异性mRNA失调
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Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.神经胰蛋白酶-神经调节蛋白1信号的消融会失衡ErbB4抑制网络并破坏海马体γ振荡。
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Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress.神经纤溶酶失活对慢性应激诱导的抑郁样行为和记忆损伤具有保护作用。
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Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues.年龄相关的认知衰退：对分子开关和恢复途径的见解
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海马体中一种新型边缘丝氨酸蛋白酶基因的表达及活性依赖性变化

Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.

作者信息

Chen Z L, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H

机构信息

Department of Structural Cellular Biology, Nara Institute of Science and Technology (NAIST), Japan.

出版信息

J Neurosci. 1995 Jul;15(7 Pt 2):5088-97. doi: 10.1523/JNEUROSCI.15-07-05088.1995.

DOI:10.1523/JNEUROSCI.15-07-05088.1995
PMID:7623137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6577896/
Abstract

A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that neuropsin mRNA is expressed specifically in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Direct hippocampal stimulation and kindling induced by amygdaloid stimulation caused a significant bilateral change in neuropsin mRNA level in the hippocampal pyramidal neurons. The activity-dependent changes and the specific localization indicate that neuropsin is involved in hippocampal plasticity.

摘要

克隆出一种编码名为神经胰蛋白酶的蛋白质的新型小鼠cDNA。Northern杂交和原位杂交分析表明，神经胰蛋白酶mRNA在小鼠脑边缘系统中特异性表达，且在海马CA1 - 3亚区的锥体神经元中浓度最高。直接海马刺激和杏仁核刺激诱导的点燃导致海马锥体神经元中神经胰蛋白酶mRNA水平发生显著的双侧变化。这种活性依赖性变化和特定定位表明神经胰蛋白酶参与了海马可塑性。