Hyodo A, Reger S I, Negami S, Kambic H, Reyes E, Browne E Z
Department of Biomedical Engineering, Cleveland Clinic Foundation, Ohio, USA.
Plast Reconstr Surg. 1995 Aug;96(2):421-8. doi: 10.1097/00006534-199508000-00025.
This study evaluated a newly developed swine monoplegic pressure sore model by testing the uniformity of the initial wound size. The natural healing also was evaluated. Nine minipigs were used. The hindlimb was denervated by transecting the unilateral nerve roots L1 through S2. At 5 to 14 days, 800 mmHg of pressure was applied to the denervated skin over the trochanteric area with a 3-cm-diameter disk compressing the skin and subcutaneous tissue against the underlying bone for 48 hours. The wound was then debrided of devascularized tissue. Wound surface areas were calculated from photographs. Wound volumes were obtained by measuring the volume of saline needed to fill the wound defect. Full-thickness sores of uniform size developed in all pigs without mortality or complications. Wound surface area and volume increased initially, peaked, and then decreased in an exponential fashion. This model provides a new tool for direct comparison of pressure sore treatment modalities for short- and long-term studies.
本研究通过测试初始伤口大小的均匀性，评估了一种新开发的猪单瘫性压疮模型。同时也对自然愈合情况进行了评估。使用了9只小型猪。通过横断单侧L1至S2神经根使后肢去神经支配。在5至14天时，用直径3厘米的圆盘将转子区去神经支配的皮肤压在下面的骨头上，对其施加800毫米汞柱的压力，持续48小时。然后清除伤口内的无血管组织。根据照片计算伤口表面积。通过测量填充伤口缺损所需的生理盐水体积获得伤口体积。所有猪均出现大小均匀的全层溃疡，无死亡或并发症。伤口表面积和体积最初增加，达到峰值，然后呈指数下降。该模型为短期和长期研究中直接比较压疮治疗方式提供了一种新工具。
