新型大环内酯类药物罗他霉素对伯氏疏螺旋体的体外活性
In vitro activity of rokitamycin, a new macrolide, against Borrelia burgdorferi.
作者信息
Cinco M, Padovan D, Stinco G, Trevisan G
机构信息
Institute of Microbiology, University of Trieste, Italy.
出版信息
Antimicrob Agents Chemother. 1995 May;39(5):1185-6. doi: 10.1128/AAC.39.5.1185.
The activity of rokitamycin, a new macrolide with a 16-member ring, was tested against Borrelia burgdorferi in vitro. The antibiotic had a lower MIC at which 50% of the isolates are inhibited than erythromycin, the parent 14-member macrolide, but the same MIC at which 50% of the isolates are inhibited as the other recent 14- and 15-member macrolides, like clarithromycin and azithromycin. The MBC was equal to the MIC at which 50% of the isolates are inhibited, so rokitamycin can be considered bactericidal against B. burgdorferi. The sensitivity of the Borrelia strains tested was not correlated with the particular species Burgdorferi sensu stricto, B. garinii, and B. afzelii or with the number of subcultures of the isolates.
对一种新型16元环大环内酯类抗生素罗他霉素针对伯氏疏螺旋体进行了体外活性测试。该抗生素对50%分离株产生抑制作用时的最低抑菌浓度（MIC）低于其母体14元环大环内酯类抗生素红霉素，但与其他近期的14元和15元环大环内酯类抗生素（如克拉霉素和阿奇霉素）对50%分离株产生抑制作用时的MIC相同。最低杀菌浓度（MBC）等于对50%分离株产生抑制作用时的MIC，因此罗他霉素可被认为对伯氏疏螺旋体具有杀菌作用。所测试的伯氏疏螺旋体菌株的敏感性与狭义伯氏疏螺旋体、伽氏疏螺旋体和阿氏疏螺旋体的特定菌种或分离株的传代次数无关。
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