al-Harbi M M, Islam M W, al-Shabanah O A, al-Gharably N M
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Food Chem Toxicol. 1995 Jul;33(7):553-8. doi: 10.1016/0278-6915(95)00021-s.
The fish oil commercially known as Marine-25 (omega-3 marine triglyceride) is an eicosapentaenoic acid (EPA)-rich oil. It was investigated for its ability to inhibit gastric secretion and to protect the gastric mucosa against the injuries caused by pyloric ligation, non-steroidal anti-inflammatory drugs (NSAIDs--aspirin and indomethacin), reserpine, hypothermic restraint stress and necrotizing agents [0.6 M HCl 0.2 M NaOH or 80% (v/v) aqueous ethanol]. The results showed that the fish oil, at a dose of 5 or 10 ml/kg body weight, provided significant protection in the various experimental models used. It produced a significant inhibition of gastric mucosal damage induced by pyloric ligation, NSAIDs, reserpine or hypothermic restraint ulcers. Fish oil also exerted a significant inhibitory action on gastric mucosal lesions produced by various necrotizing agents. Our findings show that fish oil rich in eicosapentaenoic acid possesses both antisecretory and antiulcerogenic effects.
市售名为Marine-25（ω-3海洋甘油三酯）的鱼油是一种富含二十碳五烯酸（EPA）的油。对其抑制胃酸分泌以及保护胃黏膜免受幽门结扎、非甾体抗炎药（NSAIDs——阿司匹林和吲哚美辛）、利血平、低温束缚应激和坏死剂[0.6 M盐酸、0.2 M氢氧化钠或80%（v/v）乙醇水溶液]所造成损伤的能力进行了研究。结果表明，以5或10 ml/kg体重的剂量给予鱼油，在所使用的各种实验模型中均提供了显著的保护作用。它对幽门结扎、NSAIDs、利血平或低温束缚溃疡所诱导的胃黏膜损伤产生了显著抑制作用。鱼油对各种坏死剂所造成的胃黏膜损伤也发挥了显著的抑制作用。我们的研究结果表明，富含二十碳五烯酸的鱼油具有抗分泌和抗溃疡作用。
