特应性：芬兰慢性支气管炎的一个诱发因素。
Atopy: a predisposing factor for chronic bronchitis in Finland.
作者信息
Terho E O, Koskenvuo M, Kaprio J
机构信息
Department of Clinical Allergology, University of Turku, Finland.
出版信息
J Epidemiol Community Health. 1995 Jun;49(3):296-8. doi: 10.1136/jech.49.3.296.
STUDY OBJECTIVE
To investigate the predictive value of atopy, smoking, and living in a farm environment in the development of chronic bronchitis.
DESIGN
This was a cross sectional and longitudinal study.
SETTING
Postal surveys carried out in Finland in 1975 and 1981.
PARTICIPANTS
The study was part of the Finnish twin cohort study, which included adult twin pairs born in Finland before 1958. The cross sectional sample consisted of 18,351 subjects, including 1025 prevalent cases, and the follow up sample comprised 17,134 subjects, 553 of whom were incident cases of chronic bronchitis.
MAIN RESULTS
According to the cross sectional data, chronic bronchitis was associated with atopy (relative risk 1.41) and smoking (2.43). In the follow up data, chronic bronchitis was related to atopy (1.28), smoking (2.31), and farming (1.45).
CONCLUSIONS
The results confirm the earlier finding in the Finnish farming population that, in addition to smoking, atopy predisposes the development of chronic bronchitis. A farm environment was also found to be a predisposing factor. The results give further support to the "Dutch hypothesis" on the etiology of chronic bronchitis, according to which atopy is a predisposing factor.
研究目的
探讨特应性、吸烟以及生活在农场环境中对慢性支气管炎发病的预测价值。
设计
这是一项横断面和纵向研究。
地点
1975年和1981年在芬兰进行的邮政调查。
参与者
该研究是芬兰双胞胎队列研究的一部分，包括1958年以前在芬兰出生的成年双胞胎对。横断面样本包括18351名受试者，其中包括1025例现患病例，随访样本包括17134名受试者，其中553例为慢性支气管炎新发病例。
主要结果
根据横断面数据，慢性支气管炎与特应性（相对危险度1.41）和吸烟（2.43）有关。在随访数据中，慢性支气管炎与特应性（1.28）、吸烟（2.31）和务农（1.45）有关。
结论
结果证实了芬兰务农人群中早期的发现，即除吸烟外，特应性也易导致慢性支气管炎的发生。还发现农场环境是一个诱发因素。这些结果进一步支持了关于慢性支气管炎病因的“荷兰假说”，根据该假说，特应性是一个诱发因素。
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