Chen W R, Adams R L, Bartels K E, Nordquist R E
Oklahoma School of Science and Mathematics, Oklahoma City 73104, USA.
Cancer Lett. 1995 Aug 1;94(2):125-31. doi: 10.1016/0304-3835(95)03837-m.
Rat mammary tumors were treated using an 808-nm diode laser in a power range of 3-15 W. Photothermolysis was selectively enhanced by the chromophore indocyanine green (ICG), which has an absorption peak corresponding to the laser wavelength. ICG, injected into neoplastic tissues 24 h before laser exposure, was retained in sufficient quantity to produce a strong photothermal reaction. With appropriate laser power and adequate irradiation duration, laser energy could inflict severe photothermal damage to the entire targeted tumor tissue while leaving the skin and other interdicted tissue undamaged. Higher laser powers (10-15 W) produced more surface damage that limited light transmission and as a result gave rise to reduced regions of thermal destruction. Post-treatment observation revealed the survival of numerous tumor cells. This finding questions the long term efficacy of the photothermal effect of a single treatment using the combination of the ICG and the diode laser, particularly in the absence of other modalities.
使用功率范围为3 - 15W的808纳米二极管激光对大鼠乳腺肿瘤进行治疗。生色团吲哚菁绿（ICG）可选择性增强光热解作用，其吸收峰与激光波长相对应。在激光照射前24小时将ICG注入肿瘤组织，其保留的量足以产生强烈的光热反应。在适当的激光功率和足够的照射持续时间下，激光能量可对整个目标肿瘤组织造成严重的光热损伤，同时使皮肤和其他受影响的组织不受损伤。较高的激光功率（10 - 15W）会产生更多的表面损伤，限制光的传输，从而导致热破坏区域减小。治疗后的观察发现大量肿瘤细胞存活。这一发现对使用ICG和二极管激光联合进行单次治疗的光热效应的长期疗效提出了质疑，特别是在没有其他治疗方式的情况下。
