Morton C A, Garioch J, Todd P, Lamey P J, Forsyth A
Contact Dermatitis Investigation Unit, Glasgow Royal Infirmary, UK.
Contact Dermatitis. 1995 May;32(5):281-4. doi: 10.1111/j.1600-0536.1995.tb00781.x.
We report 12 cases of contact sensitivity to the flavouring agents menthol and peppermint oil in patients presenting with intra-oral symptoms in association with burning mouth syndrome, recurrent oral ulceration or a lichenoid reaction. The patients were referred from the Glasgow Dental Hospital over a 4-year period for assessment of the possible contribution of contact sensitivity to their complaints. 5 patients with burning mouth syndrome demonstrated contact sensitivity to menthol and/or peppermint, with 1 patient sensitive to both agents, 3 positive to menthol only and 1 to peppermint only. 4 cases with recurrent intra-oral ulceration were sensitive to both menthol and peppermint. 3 patients with an oral lichenoid reaction were positive to menthol on patch testing, with 2 also sensitive to peppermint. 9 of the 12 cases demonstrated additional positive patch test results. After a mean follow-up of 32.7 months (range 9-48 months), of the 9 patients that could be contacted, 6 patients described clearance or improvement of their symptoms as a consequence of avoidance of menthol/peppermint.
我们报告了12例对调味剂薄荷醇和薄荷油产生接触性敏感的病例，这些患者伴有口腔内症状，与灼口综合征、复发性口腔溃疡或苔藓样反应相关。在4年时间里，这些患者从格拉斯哥牙科医院转诊过来，以评估接触性敏感对其主诉可能产生的影响。5例灼口综合征患者对薄荷醇和/或薄荷表现出接触性敏感，其中1例对两种试剂均敏感，3例仅对薄荷醇呈阳性反应，1例仅对薄荷呈阳性反应。4例复发性口腔溃疡患者对薄荷醇和薄荷均敏感。3例口腔苔藓样反应患者在斑贴试验中对薄荷醇呈阳性反应，其中2例对薄荷也敏感。12例中的9例在斑贴试验中还出现了其他阳性结果。平均随访32.7个月（范围9 - 48个月）后，在9例能够取得联系的患者中，6例患者表示由于避免接触薄荷醇/薄荷，其症状得以消除或改善。
