测量呼出气体以及估算挥发性有机化合物（VOCs）暴露量和体内负担方面的最新进展。
Recent advances in measuring exhaled breath and estimating exposure and body burden for volatile organic compounds (VOCs).
作者信息
Wallace L A, Pellizzari E D
机构信息
Atmospheric Research and Exposure Assessment Laboratory, Warrenton, VA 22091, USA.
出版信息
Environ Health Perspect. 1995 Apr;103 Suppl 3(Suppl 3):95-8. doi: 10.1289/ehp.95103s395.
Abstract
An improved portable breath measurement method has been developed that allows 1-min sampling times. The equipment has been successfully tested in field and chamber studies. Results of these studies suggest that breath levels following known exposures are predictable and reproducible across a small number of volunteers. The residence times in the body and the distribution in body compartments of several common air toxics have been determined. A simple four-compartment linear model is capable of fitting the observed data. The main parameters of the model include the fraction f of the parent compound exhaled under steady-state conditions and the residence times tau i, in the tau ith compartment. The values of these parameters for several VOCs and for the four body compartments (blood, vessel-rich tissues, vessel-poor tissues, and fat) are provided.
摘要
已开发出一种改进的便携式呼吸测量方法，该方法允许1分钟的采样时间。该设备已在现场和实验室研究中成功测试。这些研究结果表明，在少数志愿者中，已知暴露后的呼吸水平是可预测且可重复的。已确定了几种常见空气毒物在体内的停留时间及其在身体各部分的分布。一个简单的四室线性模型能够拟合观测数据。该模型的主要参数包括稳态条件下呼出母体化合物的分数f以及在第i个室中的停留时间τi。提供了几种挥发性有机化合物以及四个身体部分（血液、富血管组织、贫血管组织和脂肪）的这些参数值。
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本文引用的文献
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