Koreshkova S V, Tanirbergenov T B, Tarasov V A
Genetika. 1995 Jun;31(6):861-4.
When studying the carcinogenic activity of a compound, one of the basic problems is to determine the predictability of the methods used for testing; in our opinion, the most promising method is the SOS chromotest. To evaluate the test, we sampled 25 substances with a known carcinogenic activity, which had not been tested with the SOS chromotest before. Properties of the SOS chromotest were analyzed on the basis of a database containing 154 substances at present, which are characterized with regard to the presence or absence of a carcinogenic effect in rodents. The results are distributed as follows: 121 carcinogens, of which 79 positively respond to the SOS chromotest; 33 noncarcinogenes, of which 28 negatively respond to the SOS chromotest. The sensitivity and specificity of the SOS chromotest were measured as 65.3 and 84.9%, respectively. Comparing the results obtained with the Ames test and with the SOS chromotest, it was shown that the tests were similar in sensitivity and specificity. A similar predictability of both methods was also recorded.
在研究一种化合物的致癌活性时，一个基本问题是确定所使用测试方法的可预测性；在我们看来，最有前景的方法是SOS色变试验。为了评估该测试，我们选取了25种具有已知致癌活性且之前未用SOS色变试验进行测试的物质。基于目前包含154种物质的数据库分析了SOS色变试验的特性，这些物质根据在啮齿动物中是否存在致癌作用进行了表征。结果分布如下：121种致癌物，其中79种对SOS色变试验呈阳性反应；33种非致癌物，其中28种对SOS色变试验呈阴性反应。SOS色变试验的敏感性和特异性分别测定为65.3%和84.9%。将所得结果与艾姆斯试验和SOS色变试验的结果进行比较，结果表明这两种试验在敏感性和特异性方面相似。还记录到两种方法具有相似的可预测性。
