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1
High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.高水平的抗1型人类免疫缺陷病毒（HIV-1）记忆性细胞毒性T淋巴细胞活性和低病毒载量与HIV-1感染的长期不进展者无疾病状态相关。
J Virol. 1995 Sep;69(9):5838-42. doi: 10.1128/JVI.69.9.5838-5842.1995.
2
Relationship between human immunodeficiency virus type 1 (HIV-1)-specific memory cytotoxic T lymphocytes and virus load after recent HIV-1 seroconversion.1型人类免疫缺陷病毒（HIV-1）特异性记忆细胞毒性T淋巴细胞与近期HIV-1血清转化后病毒载量之间的关系。
J Infect Dis. 2001 Dec 1;184(11):1465-9. doi: 10.1086/324488. Epub 2001 Nov 13.
3
Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors.在1型人类免疫缺陷病毒（HIV-1）感染的长期存活者中，1型人类免疫缺陷病毒特异性细胞毒性T淋巴细胞活性与HIV-1病毒载量呈负相关。
AIDS Res Hum Retroviruses. 1999 Sep 1;15(13):1219-28. doi: 10.1089/088922299310313.
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A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection.1型/2型反应平衡与人类免疫缺陷病毒1型长期非进展性感染相关。
J Virol. 2002 Sep;76(18):9011-23. doi: 10.1128/jvi.76.18.9011-9023.2002.
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Relationship of virologic, immunologic, and clinical parameters in infants with vertically acquired human immunodeficiency virus type 1 infection.1型垂直感染人类免疫缺陷病毒婴儿的病毒学、免疫学和临床参数之间的关系
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Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection.早期人类免疫缺陷病毒1型感染中的细胞毒性T细胞反应、病毒载量及疾病进展
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Anti-HIV type 1 memory cytotoxic T lymphocyte responses associated with changes in CD4+ T cell numbers in progression of HIV type 1 infection.
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The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course?HIV-1感染的自然史：病毒载量和病毒表型是临床病程的独立决定因素吗？
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Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.将HIV-1特异性细胞毒性T淋巴细胞转移至一名艾滋病患者体内会导致对HIV突变体的选择以及随后的疾病进展。
Nat Med. 1995 Apr;1(4):330-6. doi: 10.1038/nm0495-330.
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Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity.人类免疫缺陷病毒（HIV）感染长期存活者体内的病毒载量是抗HIV CD8 +淋巴细胞活性的一个决定因素。
J Infect Dis. 1995 Aug;172(2):329-39. doi: 10.1093/infdis/172.2.329.

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Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes.HIV通过宿主载脂蛋白B mRNA编辑酶催化多肽样3G/F（APOBEC3G/F）酶的作用逃避适应性免疫。
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The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis.γ干扰素在HIV-1发病机制、治疗及预防中的意义
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本文引用的文献

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells.通过耗尽抗病毒细胞毒性效应T细胞，病毒在急性感染的免疫健全小鼠中持续存在。
Nature. 1993 Apr 22;362(6422):758-61. doi: 10.1038/362758a0.
2
Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.循环中的HIV特异性CD8 + 细胞毒性T细胞表达CD38和HLA - DR抗原。
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Virulent HIV strains?毒性强的艾滋病毒毒株？
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Effects of adoptive immunotherapy with autologous CD8+ T lymphocytes on immunologic parameters: lymphocyte subsets and cytotoxic activity.自体CD8 + T淋巴细胞过继性免疫疗法对免疫参数的影响：淋巴细胞亚群和细胞毒性活性。
Clin Immunol Immunopathol. 1993 Sep;68(3):263-72. doi: 10.1006/clin.1993.1127.
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Lifespans of naive, memory and effector lymphocytes.初始、记忆和效应淋巴细胞的寿命。
Curr Opin Immunol. 1993 Jun;5(3):433-8. doi: 10.1016/0952-7915(93)90065-z.
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Multifactorial nature of human immunodeficiency virus disease: implications for therapy.人类免疫缺陷病毒疾病的多因素性质：对治疗的影响。
Science. 1993 Nov 12;262(5136):1011-8. doi: 10.1126/science.8235617.
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Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.1型人类免疫缺陷病毒原发性综合征中细胞免疫反应与病毒血症初始控制的时间关联。
J Virol. 1994 Jul;68(7):4650-5. doi: 10.1128/JVI.68.7.4650-4655.1994.
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Enhanced expression of human immunodeficiency virus type 1 correlates with development of AIDS.人类免疫缺陷病毒1型的表达增强与艾滋病的发展相关。
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Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.人类免疫缺陷病毒1型（HIV-1）感染不同阶段HIV-1特异性细胞毒性T淋巴细胞（CTL）反应的定量分析：疾病晚期对HIV-1和爱泼斯坦-巴尔病毒的不同CTL反应
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Regulation of HIV expression by viral genes and cytokines.
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高水平的抗1型人类免疫缺陷病毒（HIV-1）记忆性细胞毒性T淋巴细胞活性和低病毒载量与HIV-1感染的长期不进展者无疾病状态相关。

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.

作者信息

Rinaldo C, Huang X L, Fan Z F, Ding M, Beltz L, Logar A, Panicali D, Mazzara G, Liebmann J, Cottrill M

机构信息

Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA.

出版信息

J Virol. 1995 Sep;69(9):5838-42. doi: 10.1128/JVI.69.9.5838-5842.1995.

DOI:10.1128/JVI.69.9.5838-5842.1995
PMID:7637030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189455/
Abstract

Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.

摘要

与疾病进展处于中期和晚期的患者相比，长期感染1型人类免疫缺陷病毒（HIV-1）却未发病的患者，其外周血单核细胞和血浆中的HIV-1 DNA和RNA拷贝数极低，且存在高水平的针对Gag、Pol和Env的抗HIV-1 CD8+记忆性细胞毒性T淋巴细胞。CD8+记忆性细胞毒性T淋巴细胞可能在控制HIV-1复制及预防长期不进展者发病方面发挥重要作用。