高水平的抗1型人类免疫缺陷病毒（HIV-1）记忆性细胞毒性T淋巴细胞活性和低病毒载量与HIV-1感染的长期不进展者无疾病状态相关。
High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.
作者信息
Rinaldo C, Huang X L, Fan Z F, Ding M, Beltz L, Logar A, Panicali D, Mazzara G, Liebmann J, Cottrill M
机构信息
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA.
出版信息
J Virol. 1995 Sep;69(9):5838-42. doi: 10.1128/JVI.69.9.5838-5842.1995.
Abstract
Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.
摘要
与疾病进展处于中期和晚期的患者相比，长期感染1型人类免疫缺陷病毒（HIV-1）却未发病的患者，其外周血单核细胞和血浆中的HIV-1 DNA和RNA拷贝数极低，且存在高水平的针对Gag、Pol和Env的抗HIV-1 CD8+记忆性细胞毒性T淋巴细胞。CD8+记忆性细胞毒性T淋巴细胞可能在控制HIV-1复制及预防长期不进展者发病方面发挥重要作用。
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High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors.高水平的抗1型人类免疫缺陷病毒（HIV-1）记忆性细胞毒性T淋巴细胞活性和低病毒载量与HIV-1感染的长期不进展者无疾病状态相关。
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