Crotty T B, Farrow G M, Lieber M M
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
J Urol. 1995 Sep;154(3):964-7. doi: 10.1016/s0022-5347(01)66944-1.
We review the clinicopathological features of chromophobe cell renal carcinoma.
Cases were identified by reviewing the histology of all renal neoplasms resected between 1977 and 1990. Clinical data were obtained by chart review.
Of 50 cases a majority (53%) were discovered incidentally and most (86%) were stage I. Typical pathological findings included the presence of 2 cell types (pale and eosinophilic), reactivity for Hale's colloidal iron, ultrastructural cytoplasmic vesicles and deoxyribonucleic acid aneuploidy. At last followup 47 patients (94%) were tumor-free or dead of unrelated causes. Survival was similar in patients with clear cell carcinoma of similar grade and stage.
Chromophobe cell carcinoma is a morphologically distinctive neoplasm with a favorable prognosis. Distinction from renal oncocytoma is important.
我们回顾嫌色细胞肾细胞癌的临床病理特征。
通过回顾1977年至1990年间切除的所有肾肿瘤的组织学来确定病例。通过查阅病历获得临床资料。
在50例病例中，大多数（53%）是偶然发现的，大多数（86%）为I期。典型的病理表现包括存在两种细胞类型（淡染和嗜酸性）、对Hale胶体铁呈阳性反应、超微结构的胞质小泡和脱氧核糖核酸非整倍体。在最后一次随访时，47例患者（94%）无肿瘤或死于无关原因。相似分级和分期的透明细胞癌患者的生存率与之相似。
嫌色细胞癌是一种形态学上独特的肿瘤，预后良好。将其与肾嗜酸细胞瘤区分开来很重要。
