Grant M R, Godiard L, Straube E, Ashfield T, Lewald J, Sattler A, Innes R W, Dangl J L
Max-Delbrück Laboratory, Köln, Germany.
Science. 1995 Aug 11;269(5225):843-6. doi: 10.1126/science.7638602.
Plants can recognize pathogens through the action of disease resistance (R) genes, which confer resistance to pathogens expressing unique corresponding avirulence (avr) genes. The molecular basis of this gene-for-gene specificity is unknown. The Arabidopsis thaliana RPM1 gene enables dual specificity to pathogens expressing either of two unrelated Pseudomonas syringae avr genes. Despite this function, RPM1 encodes a protein sharing molecular features with recently described single-specificity R genes. Surprisingly, RPM1 is lacking from naturally occurring, disease-susceptible Arabidopsis accessions.
植物能够通过抗病（R）基因的作用识别病原体，这些基因赋予植物对表达独特相应无毒（avr）基因的病原体的抗性。这种基因对基因特异性的分子基础尚不清楚。拟南芥RPM1基因对表达两种不相关丁香假单胞菌avr基因中任何一种的病原体具有双重特异性。尽管有此功能，但RPM1编码的蛋白质与最近描述的单特异性R基因具有共同的分子特征。令人惊讶的是，在天然存在的、感病的拟南芥种质中不存在RPM1。
