吸入速尿与哮喘儿童运动诱发性支气管收缩
Inhaled frusemide and exercise-induced bronchoconstriction in children with asthma.
作者信息
Munyard P, Chung K F, Bush A
机构信息
Department of Paediatrics, National Heart and Lung Institute, London, UK.
出版信息
Thorax. 1995 Jun;50(6):677-9. doi: 10.1136/thx.50.6.677.
BACKGROUND
Nebulised frusemide has been shown to be protective against bronchoconstricting stimuli in adult asthmatic subjects and against cold air challenge in children. Animal studies suggest that inhaled frusemide may be more effective in the young.
METHODS
A double blind placebo, controlled, crossover study on the effect on exercise of pretreatment with frusemide (20 mg) from a metered dose inhaler via a large volume spacer (Volumatic) was performed in 12 asthmatic children. Exercise testing consisted of eight minutes of running on a treadmill in an environmentally controlled laboratory.
RESULTS
Deterioration in lung function was less after frusemide than after the placebo exercise tests. The mean (95% CI) maximum percentage falls in forced expiratory volume in one second (FEV1) were 14.4% (7.7 to 21.0) for placebo and 5.7% (2.3 to 9.0) for frusemide.
CONCLUSIONS
Inhaled frusemide via a metered dose inhaler reduces exercise-induced bronchoconstriction in children.
背景
雾化速尿已被证明对成年哮喘患者的支气管收缩刺激具有保护作用，对儿童的冷空气激发试验也有保护作用。动物研究表明，吸入速尿对年幼者可能更有效。
方法
对12名哮喘儿童进行了一项双盲、安慰剂对照、交叉研究，通过大容量储雾罐（Volumatic）使用定量吸入器给予速尿（20毫克）预处理，观察其对运动的影响。运动测试包括在环境可控的实验室跑步机上跑步8分钟。
结果
速尿治疗后肺功能的恶化程度低于安慰剂运动试验后。安慰剂组一秒用力呼气量（FEV1）的平均（95%可信区间）最大下降百分比为14.4%（7.7至21.0），速尿组为5.7%（2.3至9.0）。
结论
通过定量吸入器吸入速尿可减轻儿童运动诱发的支气管收缩。
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