Vogt P M, Andree C, Breuing K, Liu P Y, Slama J, Helo G, Eriksson E
Division of Plastic Surgery, Brigham/Children's/Harvard, Boston, MA 02115, USA.
Ann Plast Surg. 1995 May;34(5):493-9; discussion 499-500. doi: 10.1097/00000637-199505000-00007.
Effects of wet (saline in a vinyl chamber), moist (hydrocolloid dressing), and dry (sterile gauze dressing) environments on wound repair were studied in a porcine partial-thickness wound model. Chambers were exchanged and refilled daily with normal saline containing penicillin G (100 U/ml) and streptomycin (100 micrograms/ml). Hydrocolloid and gauze dressings were kept in place until biopsy of the wound site. Wounds in wet, moist, and dry environments were completely epithelialized on days 6, 7, and 8, respectively. Thickness of the epidermis in wet, moist, and dry wounds was 204 +/- 23, 141 +/- 12, and 129 +/- 18 (mean +/- SEM), respectively. Moist wounds had more subepidermal inflammatory cells than wet wounds. In comparison to dry wounds, the moist or the wet healing environment resulted in less necrosis and faster and better quality of healing in the formation of the newly regenerated epidermis.
在猪的部分厚度伤口模型中，研究了湿润（乙烯基腔室中的生理盐水）、潮湿（水胶体敷料）和干燥（无菌纱布敷料）环境对伤口修复的影响。腔室每天更换并用含有青霉素G（100 U/ml）和链霉素（100微克/ml）的生理盐水重新填充。水胶体和纱布敷料保持原位直至对伤口部位进行活检。处于湿润、潮湿和干燥环境中的伤口分别在第6、7和8天完全上皮化。湿润、潮湿和干燥伤口的表皮厚度分别为204±23、141±12和129±18（平均值±标准误）。潮湿伤口的表皮下炎症细胞比湿润伤口更多。与干燥伤口相比，湿润或湿润的愈合环境导致坏死更少，新再生表皮形成时愈合速度更快且质量更好。
