Ura K, Hayes J J, Wolffe A P
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-2710, USA.
EMBO J. 1995 Aug 1;14(15):3752-65. doi: 10.1002/j.1460-2075.1995.tb00045.x.
Nucleosome mobility facilitates the transcription of chromatin templates containing only histone octamers. Inclusion of linker histones in chromatin inhibits nucleosome mobility, directs nucleosome positioning and represses transcription. Transcriptional repression by linker histone occurs preferentially on templates associated with histone octamers relative to naked DNA. Mobile nucleosomes and the restriction of mobility by linker histones might be expected to exert a major influence on the accessibility of chromatin to regulatory molecules.
核小体的移动性有助于仅包含组蛋白八聚体的染色质模板的转录。在染色质中包含连接组蛋白会抑制核小体的移动性，指导核小体定位并抑制转录。连接组蛋白介导的转录抑制相对于裸露的DNA优先发生在与组蛋白八聚体相关的模板上。移动的核小体以及连接组蛋白对移动性的限制可能会对染色质对调节分子的可及性产生重大影响。
