Opp M R, Smith E M, Hughes T K
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555-0428, USA.
J Neuroimmunol. 1995 Jul;60(1-2):165-8. doi: 10.1016/0165-5728(95)00066-b.
Interleukin-10 (IL-10), originally designated a cytokine synthesis inhibitory factor, inhibits the synthesis of the pro-inflammatory cytokines IL-1 and tumor necrosis factor by stimulated human and mouse monocytes/macrophages; these cytokines are involved in the regulation of sleep. To determine if IL-10 reduces spontaneous sleep, we injected murine recombinant IL-10 intracerebroventricularly into rats prior to light onset. Non-rapid eye movements sleep was reduced. The behavioral responses to IL-10 were abolished by heat-inactivation of this cytokine. We believe these to be the first observations of central nervous system actions for this cytokine. These results further support the hypothesis that cytokines are involved in the regulation of sleep, and suggest an additional mechanism whereby sleep may be altered in response to an activated immune system.
白细胞介素-10（IL-10）最初被称为细胞因子合成抑制因子，可抑制人及小鼠单核细胞/巨噬细胞受刺激后促炎细胞因子IL-1和肿瘤坏死因子的合成；这些细胞因子参与睡眠调节。为确定IL-10是否会减少自发睡眠，我们在天亮前向大鼠脑室内注射了小鼠重组IL-10。非快速眼动睡眠减少。该细胞因子经热灭活后，对IL-10的行为反应消失。我们认为这些是对该细胞因子中枢神经系统作用的首次观察。这些结果进一步支持了细胞因子参与睡眠调节的假说，并提示了一种免疫系统激活时睡眠可能改变的额外机制。
