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1
In utero rearrangements in the trithorax-related oncogene in infant leukaemias.婴儿白血病中三胸相关癌基因的宫内重排。
Nature. 1993 May 27;363(6427):358-60. doi: 10.1038/363358a0.
2
Cancer in Cumbria and in the vicinity of the Sellafield nuclear installation, 1963-90.1963年至1990年坎布里亚郡及塞拉菲尔德核设施附近地区的癌症情况。
BMJ. 1993 Jan 9;306(6870):89-94. doi: 10.1136/bmj.306.6870.89.
3
Can paternal preconceptional radiation account for the increase of leukaemia and non-Hodgkin's lymphoma in Seascale?父亲受孕前接受辐射能否解释西斯科尔白血病和非霍奇金淋巴瘤发病率的上升？
BMJ. 1993 Jun 26;306(6894):1718-21. doi: 10.1136/bmj.306.6894.1718.
4
Geographical distribution of preconceptional radiation doses to fathers employed at the Sellafield nuclear installation, West Cumbria.位于坎布里亚郡西部的塞拉菲尔德核设施工作的父亲们孕前辐射剂量的地理分布情况。
BMJ. 1993 Oct 16;307(6910):966-71. doi: 10.1136/bmj.307.6910.966.
5
Paternal exposure not to blame.父亲的接触并非罪魁祸首。
Nature. 1994 Feb 24;367(6465):678-80. doi: 10.1038/367678a0.
6
A review of the risks of leukemia in relation to parental pre-conception exposure to radiation.
Health Phys. 1995 Mar;68(3):299-310. doi: 10.1097/00004032-199503000-00001.
7
Epidemiological evidence for an infective basis in childhood leukaemia.儿童白血病感染病因的流行病学证据。
Br J Cancer. 1995 Jan;71(1):1-5. doi: 10.1038/bjc.1995.1.
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Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice.
Mutat Res. 1993 Sep;319(1):71-9. doi: 10.1016/0165-1218(93)90032-9.
9
Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men.雄性小鼠的突变频率及对男性辐射遗传危害的评估。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):542-4. doi: 10.1073/pnas.79.2.542.
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The risk of leukemia in Seascale from radiation exposure.
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白血病与塞拉菲尔德：存在遗传联系吗？

Leukaemia and Sellafield: is there a heritable link?

作者信息

Tawn E J

机构信息

Genetics Unit, Westlakes Research Institute, Geoffrey Schofield Laboratory, Cumbria, UK.

出版信息

J Med Genet. 1995 Apr;32(4):251-6. doi: 10.1136/jmg.32.4.251.

DOI:10.1136/jmg.32.4.251
PMID:7643351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1050370/
Abstract

The demonstration of a statistical association between paternal preconceptional irradiation and childhood leukaemia appeared to provide a satisfactory explanation for the excess of cases in the village of Seascale, close to the Sellafield nuclear installation, and became the basis of two legal claims for compensation. In the ensuing scientific debate the biological plausibility of a causal interpretation of this association focused on the heritability of leukaemia and a comparison of the genetic risks implied by this finding with current information on the induction of genetic damage by irradiation. After a wide ranging review of the mechanistic issues it is concluded that there is no genetic basis for a causal relationship and this, together with recent appraisals of epidemiological studies, suggests that the association between childhood leukaemia and paternal preconceptional irradiation exposure is most likely to be a chance finding.

摘要

父亲受孕前接受辐射与儿童白血病之间存在统计学关联，这似乎为靠近塞拉菲尔德核设施的西斯科尔村白血病病例过多提供了一个令人满意的解释，并成为两项索赔补偿法律诉求的依据。在随后的科学辩论中，对这种关联进行因果解释的生物学合理性集中在白血病的遗传性，以及将这一发现所隐含的遗传风险与当前关于辐射诱发遗传损伤的信息进行比较。在对相关机制问题进行广泛审查后得出结论，不存在因果关系的遗传基础，这一点连同近期对流行病学研究作出的评估表明，儿童白血病与父亲受孕前接受辐射暴露之间的关联很可能是偶然发现。