Tian N, Slaughter M M
Department of Biophysical Sciences, SUNY School of Medicine, Buffalo 14214, USA.
Vision Res. 1995 May;35(10):1359-64. doi: 10.1016/0042-6989(95)98715-l.
2-Amino-4-phosphonobutyrate (APB) is known to selectively suppress the light response of ON bipolar cells in the vertebrate retina, and reduce the b-wave of the electroretinogram (ERG) as a consequence. Using slow drug application, the progressive effect of APB was used to compare the relative response amplitudes of the b-wave and the ON bipolar cell. Simultaneous ERG recordings and ON bipolar intracellular recordings were performed in the amphibian retina. The results indicate that there is a strong positive correlation between these two waveforms. This supports the possibility that the b-wave of the ERG is the direct result of ON bipolar cell activity.
