Wright C D, Mathisen D J, Wain J C, Moncure A C, Hilgenberg A D, Grillo H C
General Thoracic Surgical Unit, Massachusetts General Hospital, Boston 02114, USA.
Ann Thorac Surg. 1995 Aug;60(2):245-8; discussion 248-9. doi: 10.1016/0003-4975(95)00377-w.
Treatment of esophageal perforation, especially when diagnosed late, remains controversial.
Twenty-eight patients were treated for thoracic esophageal perforation with reinforced primary repair regardless of time of presentation.
Fifteen patients were treated early (< 24 hours) with no deaths. Two had contained postoperative leaks, which healed. Thirteen were treated late (mean, 5.5 days) with four deaths (3 with healed repairs). Postoperative leaks occurred in 7 patients; of the leaks, 4 healed, 2 became a controlled fistula, and 1 required reoperation. Primary healing with preservation of the native esophagus was achieved in 25 patients (89%). Among the 18 patients without evidence of sepsis preoperatively, post-operative leaks developed in 2 (11%). Ten patients had evidence of sepsis preoperatively, and postoperative leaks developed in 7 (70%).
Patients who present with sepsis have an increased risk of postoperative leak and therefore should have the repair buttressed. Overall mortality was 14% and no deaths were due to persistent leaks or mediastinal sepsis. Reinforced primary repair retains the native esophagus and avoids the need for later reconstructive operations. In the absence of a nondilatable stricture or cancer, reinforced primary repair should be performed for most thoracic esophageal perforations, early or late.
食管穿孔的治疗,尤其是诊断较晚时,仍存在争议。
28例胸段食管穿孔患者接受了强化一期修复治疗,无论就诊时间如何。
15例患者早期(<24小时)接受治疗,无死亡病例。2例术后有局限性渗漏,但已愈合。13例患者接受晚期治疗(平均5.5天),4例死亡(3例修复愈合)。7例患者出现术后渗漏;其中4例渗漏愈合,2例形成可控瘘,1例需要再次手术。25例患者(89%)实现了保留原生食管的一期愈合。术前无脓毒症证据的18例患者中,2例(11%)出现术后渗漏。10例患者术前有脓毒症证据,7例(70%)出现术后渗漏。
出现脓毒症的患者术后渗漏风险增加,因此修复时应加强支撑。总体死亡率为14%,无死亡病例是由于持续性渗漏或纵隔脓毒症。强化一期修复保留了原生食管,避免了后期重建手术的需要。在没有不可扩张的狭窄或癌症的情况下,大多数胸段食管穿孔,无论早期或晚期,都应进行强化一期修复。