Pellegrini R, Martignone S, Tagliabue E, Belotti D, Bufalino R, Cascinelli N, Ménard S, Colnaghi M I
Istituto Nazionale Tumori, Milano, Italy.
Breast Cancer Res Treat. 1995 Aug;35(2):195-9. doi: 10.1007/BF00668209.
Laminin is a basement membrane glycoprotein whose expression has been widely related to cancer progression. Laminin production by primary breast carcinomas was investigated using immunohistochemistry on archival specimens from a retrospective series with long term follow-up. Laminin production was found to be independent of the clinical and pathological variables analyzed, whereas a statistically significant direct association with the expression of the laminin receptor and a negative association with the differentiation-related antigen Ca-MBr8 were observed. Survival analysis indicated that laminin positivity by itself has no prognostic significance. However, when analyzed together with the laminin receptor expression, laminin was associated with a good prognosis in receptor-negative tumors and with the worst prognosis in receptor-positive tumors.
层粘连蛋白是一种基底膜糖蛋白，其表达与癌症进展密切相关。我们运用免疫组织化学方法，对一组具有长期随访的回顾性系列存档标本进行研究，以探究原发性乳腺癌中层粘连蛋白的产生情况。结果发现，层粘连蛋白的产生与所分析的临床和病理变量无关，然而，却观察到其与层粘连蛋白受体的表达呈显著正相关，与分化相关抗原Ca-MBr8呈负相关。生存分析表明，层粘连蛋白阳性本身并无预后意义。但是，当与层粘连蛋白受体表达一同分析时，层粘连蛋白在受体阴性肿瘤中与良好预后相关，而在受体阳性肿瘤中则与最差预后相关。
