从英国莱姆病疫源地分离出的疏螺旋体的比较。

Comparison of Borrelia isolated from UK foci of Lyme disease.

作者信息

Livesley M A, Thompson I P, Rainey P B, Nuttall P A

机构信息

NERC Institute of Virology and Environmental Microbiology, Oxford, UK.

出版信息

FEMS Microbiol Lett. 1995 Aug 1;130(2-3):151-7. doi: 10.1111/j.1574-6968.1995.tb07712.x.

DOI:10.1111/j.1574-6968.1995.tb07712.x

PMID:7649436

Abstract

Restriction endonuclease digestion of linear borrelial chromosomal DNA showed that three isolates of UK Lyme disease spirochaetes differed markedly from each other and from published data for other isolates from North America and continental Europe. Analysis of linear plasmid bands revealed that UK isolates differed from each other in the number and sizes of the plasmids in isolates from different foci of UK Lyme disease. Fatty acid analysis (of fatty acid methyl ester (FAME) profiles) showed the UK isolates clustering together with the relapsing fever spirochaetes, Borrelia turicatae and Borrelia parkeri. These data are discussed in respect of current knowledge of Lyme borreliosis in the UK.

摘要

对线性疏螺旋体染色体DNA进行限制性内切酶消化后发现，英国莱姆病螺旋体的三株分离株彼此之间以及与北美和欧洲大陆其他分离株的已发表数据存在显著差异。线性质粒条带分析显示，英国分离株在英国莱姆病不同疫源地分离株的质粒数量和大小方面彼此不同。脂肪酸分析（脂肪酸甲酯（FAME）谱）表明，英国分离株与回归热螺旋体、杜氏疏螺旋体和帕克疏螺旋体聚集在一起。结合英国目前关于莱姆病螺旋体病的知识对这些数据进行了讨论。