Kuang P, Li Z, Zhang F, Tao Y, Liu J, Wu W
Department of neurology, Chinese PLA General Hospital Postgraduate military Medical School, Beijing.
J Tradit Chin Med. 1995 Jun;15(2):135-40.
The protective effects of Radix Salviae Miltiorrhizae Composita (RSMC) on cerebral ischemia in gerbils produced by unilateral ligation of left common carotid artery and on the development of ischemic cerebral edema were studied. It was found that the administration of RSMC resulted in a very significant decrease in neurological deficits and the time for exhibiting first signs of neurological deficit delayed compared with untreated animals. Although the values of specific gravity of fresh cerebral tissue on the ligated side of common carotid artery in untreated animals (1.0406 +/- 0.0039 SD) and in RSMC-treated animals (1.0453 +/- 0.0009) were decreased significantly compared to that (1.0468 +/- 0.0003) of sham-operated animals, the specific gravity of cerebral tissue in RSMC-treated animals was significantly heavier than that in untreated animals (t = 5.5022, P < 0.001), i.e. the administration of RSMC decreased the severity of cerebral edema. A significant negative correlation was found between stroke index and specific gravity, and it suggests that one of the protective mechanisms of RSMC might be related to its ameliorating cerebral edema.
研究了复方丹参（RSMC）对沙土鼠单侧结扎左颈总动脉所致脑缺血及缺血性脑水肿发展的保护作用。结果发现，与未治疗动物相比，给予RSMC可使神经功能缺损显著降低，且出现神经功能缺损首发症状的时间延迟。虽然未治疗动物（1.0406±0.0039 SD）和RSMC治疗动物（1.0453±0.0009）颈总动脉结扎侧新鲜脑组织的比重值与假手术动物（1.0468±0.0003）相比均显著降低，但RSMC治疗动物脑组织的比重明显高于未治疗动物（t = 5.5022，P < 0.001），即给予RSMC可减轻脑水肿的严重程度。发现中风指数与比重之间存在显著负相关，这表明RSMC的保护机制之一可能与其改善脑水肿有关。
