Hinshaw K D, Fiscella R, Sugar J
University of Illinois at Chicago 60612, USA.
Ophthalmic Surg. 1995 May-Jun;26(3):194-9.
Characteristics of alkalinized local anesthetics are poorly described with regard to stability and precipitation. Current fixed-volume methods of alkalinization often result in unstable, precipitated solutions of unpredictable pH. We determined a stable, nonprecipitating, anesthetic mixture and used it in a randomized double-blind crossover study of 21 patients to evaluate alkalinized anesthetic solutions in reducing pain on injection. Our solution significantly reduced pain associated with retrobulbar injection (analysis of variance, P = .0362) but not that associated with Nadbath injection. Fixed-volume alkalinization is not recommended because complications can result with the use of precipitated anesthetics.
关于稳定性和沉淀方面，碱化局部麻醉剂的特性鲜有描述。目前固定体积的碱化方法常常导致溶液不稳定、产生沉淀且pH值不可预测。我们确定了一种稳定、不沉淀的麻醉剂混合物，并将其用于21例患者的随机双盲交叉研究中，以评估碱化麻醉剂溶液在减轻注射疼痛方面的效果。我们的溶液显著减轻了与球后注射相关的疼痛（方差分析，P = 0.0362），但对与纳得巴斯注射相关的疼痛无效。不建议采用固定体积碱化法，因为使用沉淀的麻醉剂可能会引发并发症。
