Aoki N, Yamanaka T
Clin Chim Acta. 1978 Mar 1;84(1-2):99-105. doi: 10.1016/0009-8981(78)90481-3.
Concentrations of alpha-2 plasmin inhibitor, which is a primary and fast-reacting inhibitor of plasmin, were measured immunochemically in sera of patients with liver diseases and compared with normal controls. Serum level of alpha2-plasmin inhibitor was significantly decreased in liver cirrhosis and other severely affected liver diseases. The decrease appeared to be dependent upon the extent of liver damage, and the level of alpha2-plasmin inhibitor was closely correlated with parameters of liver functions of protein synthesis such as albumin concentration and cholinesterase activity in serum. The level of alpha2-plasmin inhibitor was fairly well correlated with the fibrinolysis inhibitor activity of serum. In contrast to alpha2-plasmin inhibitor, levels of alpha2-macroglobulin and alpha1-antitrypsin were increased significantly in liver cirrhosis. It was suggested that the reduction of alpha2-plasmin inhibitor level contributes substantially to the increased fibrinolytic activity observed in liver cirrhosis.
α2纤溶酶抑制剂是纤溶酶的主要快速反应抑制剂，通过免疫化学方法检测了肝病患者血清中的α2纤溶酶抑制剂浓度，并与正常对照组进行了比较。肝硬化和其他严重肝病患者血清中的α2纤溶酶抑制剂水平显著降低。这种降低似乎取决于肝损伤的程度，α2纤溶酶抑制剂水平与血清中蛋白质合成的肝功能参数如白蛋白浓度和胆碱酯酶活性密切相关。α2纤溶酶抑制剂水平与血清纤溶抑制活性有较好的相关性。与α2纤溶酶抑制剂相反，肝硬化患者血清中的α2巨球蛋白和α1抗胰蛋白酶水平显著升高。提示α2纤溶酶抑制剂水平的降低在很大程度上导致了肝硬化患者纤溶活性的增加。
