Pammer J, Horvat R, Weninger W, Ulrich W
Institute of Clinical Pathology, University of Vienna, Austria.
Pathol Res Pract. 1995 Feb;191(1):35-41. doi: 10.1016/S0344-0338(11)80920-9.
The bcl-2 proto-oncogene product inhibits apoptosis. It has been suggested that bcl-2 assists the survival of stem cells. Bcl-2 also plays a role in the development of adenomas. In salivary glands it is expressed in basal cells of striated and excretory ducts which may indicate that these cells are reserve cells. Acinar cells, myoepithelial cells and most luminal cells are negative for bcl-2. In basal cell adenomas and Warthin's tumors it is found predominantly in cells with basal cell differentiation. In pleomorphic adenomas bcl-2 is expressed mainly in basal cells of tubulo-ductal structures, at various degrees and patterns in solid and trabecular areas and at low degree in myxoid areas. In chondroid areas of pleomorphic adenomas, in myoepitheliomas and oncocytomas it is only focally expressed or missing. If the inhibition of apoptosis plays a significant role in the genesis of these neoplasms, then factors other than bcl-2 must be effective.
bcl-2原癌基因产物可抑制细胞凋亡。有人提出，bcl-2有助于干细胞存活。bcl-2在腺瘤的发生发展中也起作用。在唾液腺中，它在纹状管和排泄管的基底细胞中表达，这可能表明这些细胞是储备细胞。腺泡细胞、肌上皮细胞和大多数管腔细胞bcl-2呈阴性。在基底细胞腺瘤和沃辛瘤中，它主要存在于具有基底细胞分化的细胞中。在多形性腺瘤中，bcl-2主要在管状导管结构的基底细胞中表达，在实性和小梁状区域呈不同程度和模式表达，在黏液样区域表达程度较低。在多形性腺瘤的软骨样区域、肌上皮瘤和嗜酸细胞瘤中，它仅局灶性表达或缺失。如果细胞凋亡的抑制在这些肿瘤的发生中起重要作用，那么除bcl-2之外的其他因素必定也有作用。
