Grond S, Lynch J, Diefenbach C, Altrock K, Lehmann K A
Department of Anesthesiology and Operative Intensive Care, University of Cologne, Germany.
Anesth Analg. 1995 Sep;81(3):603-7. doi: 10.1097/00000539-199509000-00032.
Ondansetron and droperidol are both effective in the prevention of postoperative nausea and vomiting (PONV). In this randomized, double-blind study, 80 inpatients scheduled for minor gynecologic surgery received either ondansetron 8 mg intravenously (i.v.) or droperidol 2.5 mg i.v. 5 min prior to induction of isoflurane-narcotic anesthesia. PONV was absent in 68% of the patients after ondansetron and in 88% after droperidol (P < 0.05). The respective times of complete arousal from anesthesia were 171 min and 229 min (P < 0.001). After ondansetron and droperidol, the incidence of severe drowsiness, restlessness, anxiety, or dizziness was 5% and 28%, respectively (P < 0.01). Thus after minor gynecologic surgery, droperidol 2.5 mg i.v. was superior to ondansetron 8 mg i.v. in the prevention of PONV. However, relative to ondansetron, droperidol entailed an average 1-h delay in recovery from anesthesia.
昂丹司琼和氟哌利多在预防术后恶心和呕吐（PONV）方面均有效。在这项随机双盲研究中，80例计划接受小型妇科手术的住院患者在异氟烷 - 麻醉诱导前5分钟，静脉注射8毫克昂丹司琼或2.5毫克氟哌利多。使用昂丹司琼后68%的患者未出现PONV，使用氟哌利多后这一比例为88%（P < 0.05）。从麻醉中完全苏醒的时间分别为171分钟和229分钟（P < 0.001）。使用昂丹司琼和氟哌利多后，严重嗜睡、烦躁、焦虑或头晕的发生率分别为5%和28%（P < 0.01）。因此，在小型妇科手术后，静脉注射2.5毫克氟哌利多在预防PONV方面优于静脉注射8毫克昂丹司琼。然而，相对于昂丹司琼，氟哌利多会使麻醉恢复平均延迟1小时。
