Enderle J D, Engelken E J
Electrical & Systems Engineering Dept. University of Connecticut, Storrs 06269-3157, USA.
Biomed Sci Instrum. 1995;31:53-8.
A number of theories have been reported on post saccade phenomenon describing dynamic overshoot, glissadic overshoot and undershoot, and undershoot, all naturally and frequently occurring saccadic eye movements. Electrophysiological evidence for post-inhibitory rebound burst firing activity during saccadic eye movements is prevalent in the literature. However, the cause for the phenomenon is not known. Marked inhibition of neurons within the Paramedian Pontine Reticular Formation often results in post-inhibitory rebound burst firing activity at the beginning and end of a saccade. In this paper, post-inhibitory rebound burst firing activity after marked hyperpolarization is postulated to occur in the Paramedian Pontine Reticular Formation due to a low membrane threshold voltage. With this biophysical property, a single neuron is capable of firing at high rates automatically and without stimulation when released from inhibition. Simulations using the Hodgkin-Huxley model of a neuron demonstrate that a single neuron is capable of firing at high rates automatically without stimulation when released from inhibition.
关于扫视后现象已有多种理论报道，该现象描述了动态过冲、滑跳性过冲和欠冲以及欠冲，这些都是自然且频繁发生的眼球扫视运动。文献中普遍存在关于眼球扫视运动期间抑制后反弹爆发性放电活动的电生理证据。然而，该现象的原因尚不清楚。脑桥旁正中网状结构内神经元的显著抑制通常会在扫视开始和结束时导致抑制后反弹爆发性放电活动。在本文中，假定由于膜阈值电压较低，在脑桥旁正中网状结构中会出现显著超极化后的抑制后反弹爆发性放电活动。具有这种生物物理特性，单个神经元在从抑制中释放时能够自动且无需刺激地以高速率放电。使用神经元的霍奇金 - 赫胥黎模型进行的模拟表明，单个神经元在从抑制中释放时能够自动且无需刺激地以高速率放电。
