Yoshibayashi M, Kamiya T, Saito Y, Nakao K, Nishioka K, Temma S, Itoh H, Shirakami G, Matsuo H
Department of Pediatrics, National Cardiovascular Center, Osaka, Japan.
Eur J Endocrinol. 1995 Aug;133(2):207-9. doi: 10.1530/eje.0.1330207.
The aim of the present study is to establish the normal range and to determine the developmental changes of plasma brain natriuretic peptide (BNP) concentrations in children. We measured plasma BNP concentrations as well as atrial natriuretic peptide (ANP) concentrations in 58 healthy children from birth to adolescence and in the umbilical vein of 20 healthy neonates using highly sensitive immunoradiometric assays. The plasma BNP concentration was the highest at 0 days of age and descended through maturation to be almost constant and to be at the adult level at 3 months of age. The plasma BNP concentration at 0 days of age (56.7 +/- 49.6 fmol/ml; mean +/- SD) was 25 to 30 times higher than the adult level and 21 times higher than that in the umbilical vein (2.7 +/- 1.4 fmol/ml). The plasma ANP concentration at 0 days of age was not significantly different from that in the umbilical vein. The ratio of BNP to ANP was also the highest at 0 days of age (1.39 +/- 0.72) and decreased through maturation to be at the adult level at 3 months of age. Thus, the plasma BNP concentration in healthy subjects showed a marked, rapid and preferential increase immediately after birth, suggesting that BNP has a physiological role distinct from that of ANP in the perinatal circulatory changes from fetus to neonate.
本研究的目的是确定儿童血浆脑钠肽（BNP）浓度的正常范围，并明确其发育变化。我们使用高灵敏度免疫放射分析法，对58名从出生至青春期的健康儿童以及20名健康新生儿脐静脉中的血浆BNP浓度和心钠素（ANP）浓度进行了测量。血浆BNP浓度在0日龄时最高，随着发育逐渐下降，至3月龄时几乎恒定并达到成人水平。0日龄时的血浆BNP浓度（56.7±49.6 fmol/ml；均值±标准差）比成人水平高25至30倍，比脐静脉中的浓度（2.7±1.4 fmol/ml）高21倍。0日龄时的血浆ANP浓度与脐静脉中的浓度无显著差异。BNP与ANP的比值在0日龄时也最高（1.39±0.72），并随着发育下降，至3月龄时达到成人水平。因此，健康受试者的血浆BNP浓度在出生后立即呈现出显著、快速且优先的升高，这表明在从胎儿到新生儿的围产期循环变化中，BNP具有与ANP不同的生理作用。
