Iwatsuki K, Ikeda K, Chiba S
Arch Int Pharmacodyn Ther. 1981 May;251(1):166-76.
The effect of histamine on the secretion of pancreatic juice was investigated in preparations of isolated, blood-perfused dog pancreas. Histamine (3-30 microgram) injected intra-arterially caused dose-dependent increases in the secretion of pancreatic juice after a delay of a few minutes. 4-Methylhistamine (10-100 microgram), a selective histamine H2-receptor agonist, caused changes of the pancreatic secretion similar to those of histamine. Metiamide (100 microgram), a selective H2-receptor antagonist, blocked the increases of the pancreatic secretion in responses to both histamine or 4-methylhistamine. In contrast, diphenhydramine even at large doses (1 mg), a selective H1-receptor antagonist, did not effect histamine, or 4-methylhistamine-induced secretion. Histamine increased both bicarbonate and protein concentration in the juice. This action was different from that of secretion or pancreozymin. These results suggest that histamine increases pancreatic secretion acting directly on pancreatic cells through H2-receptors.
在离体、血液灌注的狗胰腺标本中研究了组胺对胰液分泌的影响。动脉内注射组胺（3 - 30微克），数分钟延迟后可引起胰液分泌呈剂量依赖性增加。4 - 甲基组胺（10 - 100微克），一种选择性组胺H2受体激动剂，引起的胰腺分泌变化与组胺相似。甲硫咪特（100微克），一种选择性H2受体拮抗剂，可阻断组胺或4 - 甲基组胺引起的胰腺分泌增加。相比之下，即使大剂量（1毫克）的苯海拉明，一种选择性H1受体拮抗剂，也不影响组胺或4 - 甲基组胺诱导的分泌。组胺增加了胰液中碳酸氢盐和蛋白质的浓度。这种作用不同于促胰液素或缩胆囊素的作用。这些结果表明，组胺通过H2受体直接作用于胰腺细胞，从而增加胰腺分泌。
