Georgiannos S N, Weston P M, Goode A W
Surgical Unit, Royal London Hospital, Whitechapel, UK.
Int Surg. 1995 Jan-Mar;80(1):49-52.
This study was designed to examine a possible relationship between plasma free positively charged amino acid concentrations and the degree of microalbuminuria in patients with gastrointestinal cancer. In 42 consecutive patients (22 men and 20 women), comprised of 25 with histologically proven colorectal or gastric cancer, 9 controls and 8 weight-losing patients with benign gastrointestinal disease urinary albumin and plasma amino acid analysis was performed. Microalbuminuria was more prevalent in weight-losing cancer patients (65%) compared with their weight-stable counterparts, benign gastrointestinal patients and controls. This difference reached statistical significance at the 5% level. Additionally, a significant positive correlation (rs = 0.8, p < 0.05) was observed between ornithine and urinary albumin loss in this group of patients. This study suggests that plasma free amino acid alterations in weight-losing gastrointestinal cancer patients may have an effect on renal tubular protein reabsorption.
本研究旨在探讨胃肠癌患者血浆游离带正电荷氨基酸浓度与微量白蛋白尿程度之间的可能关系。对42例连续患者（22例男性和20例女性）进行了尿白蛋白和血浆氨基酸分析，其中包括25例经组织学证实的结直肠癌或胃癌患者、9例对照者以及8例患有良性胃肠疾病的体重减轻患者。与体重稳定的癌症患者、良性胃肠疾病患者及对照者相比，体重减轻的癌症患者中微量白蛋白尿更为普遍（65%）。这一差异在5%水平上具有统计学意义。此外，在该组患者中，观察到鸟氨酸与尿白蛋白丢失之间存在显著正相关（rs = 0.8，p < 0.05）。本研究表明，体重减轻的胃肠癌患者血浆游离氨基酸改变可能对肾小管蛋白重吸收产生影响。
