胰腺性脂膜炎

Pancreatic panniculitis.

作者信息

Dahl P R, Su W P, Cullimore K C, Dicken C H

机构信息

Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

J Am Acad Dermatol. 1995 Sep;33(3):413-7. doi: 10.1016/0190-9622(95)91385-8.

DOI:10.1016/0190-9622(95)91385-8

PMID:7657863

Abstract

BACKGROUND

Pancreatic panniculitis is a rare disease in which necrosis of fat in the panniculus and other distant foci occurs in the setting of pancreatic disease.

OBJECTIVE

Our purpose was to study the clinical and histopathologic features of this disease.

METHODS

We conducted a retrospective review of 11 patients.

RESULTS

In five patients subcutaneous fat necrosis preceded the diagnosis of pancreatic disease by an average of 13 weeks. Five of our patients had underlying pancreatitis, and the remainder had carcinoma of the pancreas. Joint manifestations were prominent in six patients. Intestinal submucosal fat necrosis developed in two cases and caused massive gastrointestinal bleeding in one. Acute lesions demonstrated focal fat necrosis with "ghost cells," pathognomonic of this condition. Chronic lesions showed granulomatous and lipophagic panniculitis, with rare areas of basophilic fat necrosis. Cholecystectomy for gallstone pancreatitis was curative in two patients.

CONCLUSION

Pancreatic panniculitis has distinctive clinical and pathognomonic histopathologic findings that can be the presenting features of pancreatic disease.

摘要

背景

胰腺性脂膜炎是一种罕见疾病，在胰腺疾病背景下，皮下脂肪及其他远处病灶会出现脂肪坏死。

目的

我们的目的是研究该疾病的临床和组织病理学特征。

方法

我们对11例患者进行了回顾性研究。

结果

5例患者皮下脂肪坏死先于胰腺疾病诊断出现，平均提前13周。我们的患者中有5例患有潜在胰腺炎，其余患有胰腺癌。6例患者关节表现突出。2例出现肠黏膜下脂肪坏死，其中1例导致大量胃肠道出血。急性病变表现为局灶性脂肪坏死伴“鬼影细胞”，这是该病症的特征性表现。慢性病变表现为肉芽肿性和噬脂性脂膜炎，嗜碱性脂肪坏死区域少见。2例因胆石性胰腺炎行胆囊切除术的患者治愈。