Leung S Y, Yuen S T, Chung L P, Kwong W K, Wong M P, Chan S Y
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Am J Surg Pathol. 1995 Sep;19(9):994-1001. doi: 10.1097/00000478-199509000-00002.
Nasopharyngeal carcinomas, a common occurrence in Southern Chinese people, shows a strong association with Epstein-Barr virus (EBV); in the same population, sinonasal carcinomas are distinctly rare. Although most nasopharyngeal carcinomas are lymphoepitheliomas, sinonasal carcinomas have a wide morphological spectrum. We studied the clinicopathological features and EBV status of 29 sinonasal carcinomas from Hong Kong Chinese patients. By in situ hybridization using antisense Epstein-Barr virus early RNA (EBER) probe, seven tumors were shown to be strongly positive for the EBV RNA. They displayed a wide morphological spectrum, including one cylindric cell carcinoma, one intestinal type adenocarcinoma, four nonkeratinizing squamous cell carcinomas, and one undifferentiated carcinoma. All were from elderly subjects (mean age, 67), including six men and one woman. Three of these seven patients had complete remission after radiotherapy with a median follow-up period of 29 months. In two cases, EBV latent membrane protein-1 was expressed. Detection of the virus in a number of histological subtypes, including cylindric cell carcinoma and adenocarcinoma, suggests that EBV may play a role in the pathogenesis of a diverse spectrum of carcinomas.
鼻咽癌在华南地区人群中较为常见，与爱泼斯坦-巴尔病毒（EBV）密切相关；在同一人群中，鼻窦癌则极为罕见。尽管大多数鼻咽癌是淋巴上皮瘤，但鼻窦癌具有广泛的形态学谱。我们研究了29例来自中国香港患者的鼻窦癌的临床病理特征和EBV状态。通过使用反义爱泼斯坦-巴尔病毒早期RNA（EBER）探针进行原位杂交，发现7例肿瘤的EBV RNA呈强阳性。它们表现出广泛的形态学谱，包括1例圆柱细胞癌、1例肠型腺癌、4例非角化性鳞状细胞癌和1例未分化癌。所有患者均为老年患者（平均年龄67岁），其中6例男性，1例女性。这7例患者中有3例在放疗后完全缓解，中位随访期为29个月。在2例病例中，EBV潜伏膜蛋白-1呈阳性表达。在多种组织学亚型（包括圆柱细胞癌和腺癌）中检测到该病毒，提示EBV可能在多种癌的发病机制中起作用。
