Noyes B E, Katz F N, Schaffer M H
Department of Psychiarty, University of Texas Southwestern Medical School, Dallas, 75235, USA.
Mol Cell Endocrinol. 1995 Apr 1;109(2):133-41. doi: 10.1016/0303-7207(95)03492-p.
Drosophila adipokinetic hormone (DAKH) is an eight amino acid member of a large arthropod neuropeptide family. The gene encoding the peptide precursor has been identified and sequenced providing an inferred precursor structure of 79 amino acids including a 46 amino acid carboxy-terminal fragment of unknown function. In situ hybridization identifies sites of DAKH synthesis towards the base of the third larval instar ring gland. Like other RPCH (red pigment concentrating hormone)/AKH family peptides, DAKH can act as a cardioaccelerator at least in prepupae. Peptide levels measured in wildtype and mutant flies possessing one or three copies of the DAKH gene suggest that the amount of neuropeptide per fly is tightly regulated.
果蝇脂肪动激素（DAKH）是大型节肢动物神经肽家族中的一种八氨基酸成员。编码该肽前体的基因已被鉴定和测序，提供了一个由79个氨基酸组成的推断前体结构，包括一个功能未知的46个氨基酸的羧基末端片段。原位杂交确定了DAKH在第三龄幼虫环腺基部的合成位点。与其他RPCH（红色素聚集激素）/AKH家族肽一样，DAKH至少在预蛹期可作为心脏兴奋剂。在拥有一个或三个DAKH基因拷贝的野生型和突变型果蝇中测得的肽水平表明，每只果蝇的神经肽量受到严格调控。
