Rühle W, Graf von Ballestrem C L, Pult H M, Gnirs J
Medizinische Universität zu Lübeck.
Geburtshilfe Frauenheilkd. 1995 Mar;55(3):156-9. doi: 10.1055/s-2007-1022795.
The aim of the present study was to determine the correlation of cotinine levels in amniotic fluid and in fetal and corresponding maternal blood samples. Amniotic fluid samples (N = 130) were taken during second trimester amniocentesis, umbilical artery blood samples (N = 75) at birth, both together with corresponding maternal blood samples. Self-reported smokers showed maternal serum cotinine levels > 15 ng/ml in 93%, self-reported nonsmokers levels < 15 ng/ml in 89%. Correlation of corresponding values for cotinine was 0.81-0.92. Cotinine values were increased in fetal blood and amniotic fluid in comparison to maternal serum levels. Despite the fact that pathophysiology is not fully understood, an accumulation of nicotine and its metabolites both in the fetus and in the amniotic fluid appears to be evident.
本研究的目的是确定羊水、胎儿血液及相应母体血液样本中可替宁水平之间的相关性。在孕中期羊膜穿刺术时采集羊水样本（n = 130），出生时采集脐动脉血样本（n = 75），同时采集相应的母体血液样本。自我报告的吸烟者中，93%的母体血清可替宁水平> 15 ng/ml，自我报告的非吸烟者中，89%的水平< 15 ng/ml。可替宁相应值的相关性为0.81 - 0.92。与母体血清水平相比，胎儿血液和羊水中的可替宁值升高。尽管病理生理学尚未完全了解，但尼古丁及其代谢产物在胎儿和羊水中的蓄积似乎很明显。
