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采用脉冲场凝胶电泳技术对东南亚地区伤寒沙门菌分离株进行分析。

Analysis of Salmonella typhi isolates from Southeast Asia by pulsed-field gel electrophoresis.

作者信息

Thong K L, Puthucheary S, Yassin R M, Sudarmono P, Padmidewi M, Soewandojo E, Handojo I, Sarasombath S, Pang T

机构信息

Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

J Clin Microbiol. 1995 Jul;33(7):1938-41. doi: 10.1128/jcm.33.7.1938-1941.1995.

DOI:10.1128/jcm.33.7.1938-1941.1995
PMID:7665677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC228306/
Abstract

Pulsed-field gel electrophoresis (PFGE) revealed that multiple genetic variants of Salmonella typhi are simultaneously present in Southeast Asia and are associated with sporadic cases of typhoid fever and occasional outbreaks. Comparative analysis of PFGE patterns also suggested that considerable genetic diversity exists among S. typhi strains and that some PFGE patterns are shared between isolates obtained from Malaysia, Indonesia, and Thailand, implying movement of these strains within these regions of Southeast Asia, where they are endemic.

摘要

脉冲场凝胶电泳（PFGE）显示，伤寒沙门氏菌的多种基因变体同时存在于东南亚地区，且与伤寒热的散发病例和偶尔的暴发有关。PFGE图谱的比较分析还表明，伤寒沙门氏菌菌株之间存在相当大的遗传多样性，并且从马来西亚、印度尼西亚和泰国分离出的菌株之间存在一些共同的PFGE图谱，这意味着这些菌株在东南亚这些地方病流行的地区内传播。

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