Heinrich J, Velleman M, Schuster H
Max-Planck-Institut für Molekulare Genetik, Berlin, Germany.
FEMS Microbiol Rev. 1995 Aug;17(1-2):121-6. doi: 10.1111/j.1574-6976.1995.tb00193.x.
Prophages P1 and P7 exist as unit copy DNA plasmids in the bacterial cell. Maintenance of the prophage state requires the continuous expression of two repressors: (i) C1 is a protein which negatively regulates the expression of lytic genes including the C1 inactivator gene coi, and (ii) C4 is an antisense RNA which specifically inhibits the synthesis of an anti-repressor Ant. In addition, C1 repression is strengthened by lxc encoding an auxiliary repressor protein. The repressors C1, C4 and Lxc are components of a tripartite immunity system of the two phages. Here, the mode of action of these regulatory components including their antagonists Coi and Ant is described.
原噬菌体P1和P7以单位拷贝DNA质粒的形式存在于细菌细胞中。维持原噬菌体状态需要持续表达两种阻遏物：（i）C1是一种蛋白质，它负向调节包括C1灭活基因coi在内的裂解基因的表达；（ii）C4是一种反义RNA，它特异性抑制抗阻遏物Ant的合成。此外，编码辅助阻遏蛋白的lxc增强了C1的阻遏作用。阻遏物C1、C4和Lxc是这两种噬菌体三方免疫体系的组成部分。在此，描述了这些调节成分包括其拮抗剂Coi和Ant的作用方式。
