Chan-Yeung M, Grzybowski S
Can Med Assoc J. 1976 Mar 6;114(5):433-6.
Occupational asthma is probably much more common than is generally realized. Though many causes have been described, undoubtedly many more are yet to be recognized. One of the diagnostic difficulties lies in the fact that in most forms of this disease a late asthmatic reaction occurs in the evening rather than at work. The pathogenetic mechanisms differ in various forms of occupational asthma. In some, an immunologic mechanism is likely; in others, a "pharmacologic" action of the offending agent is implicated. Asthma due to inhalation of dusts of western red cedar, isocyanates, detergent enzymes and textiles is considered in detail. Periodic examination of workers at risk is of value for early diagnosis and prevention of irrversible airway obstruction.
职业性哮喘可能比人们普遍认识到的更为常见。尽管已经描述了许多病因，但毫无疑问还有更多病因有待发现。诊断困难之一在于，在这种疾病的大多数类型中，哮喘迟发反应发生在晚上而非工作时。职业性哮喘的不同类型其发病机制也有所不同。在某些类型中，可能存在免疫机制；而在另一些类型中，则涉及致病因子的“药理”作用。本文详细讨论了因吸入西部红雪松粉尘、异氰酸酯、洗涤剂酶和纺织品而引发的哮喘。对高危工人进行定期检查对于早期诊断和预防不可逆性气道阻塞具有重要价值。
