Zofková I, Kancheva R L
Institute of Endocrinology, Prague 1, Czech Republic.
Magnes Res. 1995 Mar;8(1):77-84.
There is an important functional link between magnesium and calciotropic hormones. PTH stimulates magnesium reabsorption in the renal tubule, absorption in the gut and release of the ion from bone. Magnesium on the other hand is essential for the normal function of the parathyroid glands, metabolism of vitamin D and adequate sensitivity of target tissues to PTH and active vitamin D metabolites. Magnesium deficit is usually associated with hypoparathyroidism, low production of active vitamin D metabolites, in particular 1,25(OH)2 vitamin D3 and resistance to PTH and vitamin D. On the contrary, magnesium excess, similar to calcium, inhibits PTH secretion. Bone metabolism is impaired under positive as well as under negative magnesium balance. Because of the great importance of magnesium in the regulation of calcium homoeostasis, appropriate attention should be paid to the early diagnosis and treatment of magnesium imbalance.
镁与钙调节激素之间存在重要的功能联系。甲状旁腺激素（PTH）刺激肾小管对镁的重吸收、肠道对镁的吸收以及骨中镁离子的释放。另一方面，镁对于甲状旁腺的正常功能、维生素D的代谢以及靶组织对PTH和活性维生素D代谢产物的充分敏感性至关重要。镁缺乏通常与甲状旁腺功能减退、活性维生素D代谢产物生成减少，尤其是1,25(OH)₂维生素D₃生成减少以及对PTH和维生素D的抵抗有关。相反，与钙类似，镁过量会抑制PTH分泌。在镁平衡为正或负的情况下，骨代谢都会受损。由于镁在钙稳态调节中非常重要，因此应适当关注镁失衡的早期诊断和治疗。
