Ship J A, Nolan N E, Puckett S A
Department of Oral Medicine, Pathology, and Surgery, University of Michigan School of Dentistry, USA.
J Gerontol A Biol Sci Med Sci. 1995 Sep;50(5):M285-9. doi: 10.1093/gerona/50a.5.m285.
Early studies suggested that salivary gland dysfunction was a normal sequela of aging. Recent research on healthy, different-aged adults has led to a revision of these former conclusions. Parotid gland function appears to be age-stable, yet there is no consensus on submandibular/sublingual output. To date, there have only been two longitudinal studies utilizing healthy individuals examining parotid function, and no published longitudinal studies on submandibular/sublingual output. The purpose of this study was to examine unstimulated and stimulated major salivary gland flow rates in unmedicated, essentially healthy subjects, over a 3-year period.
Thirty-seven males and females, aged 26-90 years of age, were examined twice over a 3-year period at the Clinical Center of the National Institutes of Health. All were healthy, community-dwelling adults, without systemic diseases, and not taking any medications. Unstimulated and 2% citrate-stimulated parotid and submandibular/sublingual salivary gland flow rates were assessed at both visits, and changes over time were evaluated according to the subject's age at initial visit.
There were no significant flow rate differences over a 3-year time period for unstimulated and stimulated parotid and submandibular/sublingual flow rates.
Major salivary gland output is aged-stable in healthy persons over a 3-year period. The data from this study suggest that salivary gland dysfunction in an older person should not be considered a normal process of aging.
早期研究表明唾液腺功能障碍是衰老的正常后遗症。近期针对不同年龄段健康成年人的研究导致了对这些先前结论的修正。腮腺功能似乎在年龄上保持稳定，但关于下颌下腺/舌下腺的分泌量尚无共识。迄今为止，仅有两项利用健康个体的纵向研究考察了腮腺功能，且尚无关于下颌下腺/舌下腺分泌量的已发表纵向研究。本研究的目的是在3年时间内，对未用药的基本健康受试者的非刺激性和刺激性主要唾液腺流速进行检测。
37名年龄在26至90岁之间的男性和女性，在国立卫生研究院临床中心接受了为期3年的两次检查。所有受试者均为健康的社区居住成年人，无全身性疾病，且未服用任何药物。在两次就诊时均评估了非刺激性和2%枸橼酸盐刺激后的腮腺及下颌下腺/舌下腺唾液腺流速，并根据初次就诊时受试者的年龄评估随时间的变化。
在3年时间内，非刺激性和刺激性腮腺及下颌下腺/舌下腺流速均无显著差异。
在3年时间内，健康人的主要唾液腺分泌量在年龄上保持稳定。本研究数据表明，不应将老年人的唾液腺功能障碍视为衰老的正常过程。
