Kayashima S, Ohno H, Fujioka T, Taniguchi N, Nagata N
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Eur J Appl Physiol Occup Physiol. 1995;70(5):413-20. doi: 10.1007/BF00618492.
The effects of strenuous physical exercise on the serial changes in the haematological, biochemical and hormonal markers were investigated. A group of 14 soldiers, aged 24-36 years, took part in a military training course for about 13 weeks. After severe exercise stress, an increase (90%) in the number of peripheral blood leucocytes was observed. The degree of leucocytosis showed a close correlation with the values of some serum parameters, such as concentrations of aspartate aminotransferase (AST; r = 0.747), lactate dehydrogenase (LD; r = 0.748), blood urea nitrogen (r = 0.756), creatine kinase (CK; r = 0.637), manganese-superoxide dismutase (Mn-SOD; r = 0.508), alanine aminotransferase (ALT; r = 0.542) and uric acid (r = 0.538), and concentrations of urinary parameters, such as vanilmandelic acid (r = 0.429) and free cortisol (r = 0.437). The subjects showing prominent leucocytosis over 9500 cells.microliters-1 exhibited a lower concentration of serum cholinesterase than those who showed milder leucocytosis. The serum Mn-SOD concentration was closely correlated with the serial changes in serum concentrations of AST, ALT, LD and CK, indicating exercise-induced muscle and liver damage. The change in peripheral leucocyte number was assumed to be diagnostically informative and may be a prognostic marker, reflecting organ damage and restoration after strenuous physical exercise.
研究了剧烈体育锻炼对血液学、生化和激素标志物系列变化的影响。一组14名年龄在24 - 36岁的士兵参加了为期约13周的军事训练课程。在剧烈运动应激后，观察到外周血白细胞数量增加（90%）。白细胞增多程度与一些血清参数值密切相关，如天冬氨酸转氨酶（AST；r = 0.747）、乳酸脱氢酶（LD；r = 0.748）、血尿素氮（r = 0.756）、肌酸激酶（CK；r = 0.637）、锰超氧化物歧化酶（Mn - SOD；r = 0.508）、丙氨酸转氨酶（ALT；r = 0.542）和尿酸（r = 0.538）的浓度，以及尿液参数值，如香草扁桃酸（r = 0.429）和游离皮质醇（r = 0.437）。白细胞显著增多超过9500个/微升的受试者血清胆碱酯酶浓度低于白细胞增多较轻的受试者。血清Mn - SOD浓度与AST、ALT、LD和CK血清浓度的系列变化密切相关，表明运动引起了肌肉和肝脏损伤。外周白细胞数量的变化被认为具有诊断意义，可能是一个预后标志物，反映剧烈体育锻炼后的器官损伤和恢复情况。
