Tsuboi R, Sato C, Oshita Y, Hama H, Sakurai T, Goto K, Ogawa H
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
FEBS Lett. 1995 Sep 4;371(2):188-90. doi: 10.1016/0014-5793(95)00912-s.
The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm2 increased ET-1 secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ETA and ETB receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm2 UVB irradiation.
