[日本中部地区各种眼部疾病中人类嗜T淋巴细胞病毒I型的血清流行率]

[Seroprevalence of HTLV-I in various ocular diseases in central Japan].

作者信息

Goto K, Kurita M, Watanabe N, Ogi A, Iijima Y, Hanajiri M, Saeki K, Ohno S

机构信息

Division of Ophthalmology, Odawara Municipal Hospital, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1995 Aug;99(8):959-63.

PMID:7676898

Abstract

Recently human T-cell lymphotropic virus type I (HTLV-I) has been shown to be responsible for a kind of uveitis in southwestern Japan, where HTLV-I infection is highly endemic. To investigate further the association of HTLV-I with various ocular diseases, we studied HTLV-I seroprevalence in 1,350 patients in central Japan, where HTLV-I infection is not endemic. Of 1,350 patients with various ocular diseases, 40 (2.96%) were seropositive for the retrovirus. There was no statistically significant difference in HTLV-I seroprevalence among various ocular diseases. Four of 9 (44.4%) seropositive cases from southwestern Japan developed HTLV-I associated uveitis (HAU), whereas only 2 of 26 (7.7%) seropositive cases from central Japan developed HAU. The difference was statistically significant (p < 0.05). This suggests that the incidence of HAU could be influenced by environmental or hereditary factors. On the other hand, 3 of 7 (42.9%) patients with episcleritis showed HTLV-I infection.

摘要

最近研究表明，人类嗜T淋巴细胞病毒I型（HTLV-I）是日本西南部一种葡萄膜炎的病因，该地区HTLV-I感染呈高度地方性流行。为了进一步研究HTLV-I与各种眼部疾病的关联，我们对日本中部1350例患者进行了HTLV-I血清流行率研究，该地区HTLV-I感染并非地方性流行。在1350例患有各种眼部疾病的患者中，40例（2.96%）该逆转录病毒血清学检测呈阳性。各种眼部疾病的HTLV-I血清流行率无统计学显著差异。来自日本西南部的9例（44.4%）血清学检测呈阳性的病例中有4例发展为HTLV-I相关葡萄膜炎（HAU），而来自日本中部的26例（7.7%）血清学检测呈阳性的病例中只有2例发展为HAU。差异具有统计学显著性（p < 0.05）。这表明HAU的发病率可能受环境或遗传因素影响。另一方面，7例巩膜炎患者中有3例（42.9%）显示HTLV-I感染。