Ishioka M, Goto K, Nakamura S, Watanabe N, Uchio E, Saeki K, Ohno S
Schepens Eye Research Institute, Boston, MA 02114, USA.
Graefes Arch Clin Exp Ophthalmol. 1995 Aug;233(8):476-8. doi: 10.1007/BF00183427.
Seroprevalence of antibody to human T-lymphotropic virus type I (HTLV-I) is high in the island of Kyushu, Japan. Reports on the etiological analysis of HTLV-I in patients with uveitis primarily document cases in this island. We studied the seroprevalence of HTLV-I at the Department of Ophthalmology in Yokohama City University Hospital and in Odawara Municipal Hospital, which are in the Kanto Plain on the island of Honshu, Japan.
The subjects were 741 patients who visited the two hospitals. The presence of serum antibodies against HTLV-I was assessed using the method of particle agglutination.
Of 454 patients with nonuveitic ocular diseases, 9 (1.98%) were seropositive. Of 143 patients with definite diagnosis of uveitis, 1 (0.70%) was seropositive. Of 144 patients with non-specific uveitis (etiology undefined), 8 (5.56%) were seropositive. Thus, the prevalence of serum antibodies to HTLV-I was higher in patients with non-specific uveitis than in patients with specific uveitis or nonuveitic ocular diseases. Common ocular symptoms of 8 HTLV-I-infected patients with non-specific uveitis were compatible with the clinical features of uveitis described as HTLV-I-associated uveitis (HAU).
It is important to suspect HAU in patients with uveitis of unknown etiology, even outside known areas of prevalence.
在日本九州岛，人类嗜T淋巴细胞病毒I型（HTLV-I）抗体的血清流行率很高。关于葡萄膜炎患者中HTLV-I病因分析的报告主要记录了该岛的病例。我们研究了日本本州岛关东平原的横滨市立大学医院眼科和小田原市立医院HTLV-I的血清流行率。
研究对象为741名到这两家医院就诊的患者。采用颗粒凝集法评估血清中抗HTLV-I抗体的存在情况。
在454例非葡萄膜炎性眼病患者中，9例（1.98%）血清呈阳性。在143例确诊为葡萄膜炎的患者中，1例（0.70%）血清呈阳性。在144例非特异性葡萄膜炎（病因不明）患者中，8例（5.56%）血清呈阳性。因此，非特异性葡萄膜炎患者中HTLV-I血清抗体的流行率高于特异性葡萄膜炎或非葡萄膜炎性眼病患者。8例感染HTLV-I的非特异性葡萄膜炎患者的常见眼部症状与被描述为HTLV-I相关葡萄膜炎（HAU）的葡萄膜炎临床特征相符。
即使在已知流行区域之外，对于病因不明的葡萄膜炎患者怀疑HAU也很重要。
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